home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9410o.zip
/
M94A2926.TXT
< prev
next >
Wrap
Text File
|
1994-10-25
|
3KB
|
41 lines
Document 2926
DOCN M94A2926
TI Progressive lesion of ascending sensory tracts.
DT 9412
AU Husstedt IW; Grotemeyer KH; Busch H; Hoffmann U; Zidek W; Department of
Neurology, Westf. Wilhelms-Universitat,; Munster/Germany.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):193 (abstract no. PB0201). Unique
Identifier : AIDSLINE ICA10/94369649
AB OBJECTIVE: It was the aim of our study to detect whether or not the
lesion of the ascending central and peripheral sensory tracts in
HIV-infected patients are progressive. METHODS: 36 patients (mean age
35.4 +/- 4.6 years, HIV-infection since 5.6 +/- 1.8 years (laboratory
diagnosis), 9 female, 27 male) were examined clinically and by
somatosensory evoked potentials of the median (MN) and tibial nerve (TN)
in conventional manner (10/20 system). Investigations were repeated
first 15 +/- 4 months later and second 29 +/- 6 months later. RESULTS:
Clinical investigations showed an increase of findings indicating
progressive lesion of sensory tracts (diminution of vibration,
hypesthesia, ataxia). Neurophysiological investigations showed a
statistical significant exponential increase (Friedman Nonparametric
Repeated Measures Test) for latencies of evoked potentials (MN: N13,
N19, N19-N13; TN: N21, P40, P40-N21). CONCLUSION: HIV-infection induces
an exponential progressive degeneration of the peripheral and central
ascending sensory pathways. These alterations cause a deterioration of
quality of life in HIV-infected patients. It is assumed that the
progressive lesion is of polyaetiologic nature. Besides indirectly
promoted demyelination by HI-Virus, metabolic disturbances and
neurotoxic factors like cytokines and deleterious viral products had to
be discussed.
DE Adult Afferent Pathways/PHYSIOPATHOLOGY AIDS Dementia
Complex/*DIAGNOSIS/PHYSIOPATHOLOGY Evoked Potentials,
Somatosensory/PHYSIOLOGY Female Follow-Up Studies Human HIV
Infections/*DIAGNOSIS/PHYSIOPATHOLOGY Male Neurologic Examination
Peripheral Nerves/PHYSIOPATHOLOGY Reaction Time/PHYSIOLOGY Sensation
Disorders/*DIAGNOSIS/PHYSIOPATHOLOGY Somatosensory
Cortex/PHYSIOPATHOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).